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目的：探讨延回头端腹外侧区（RVLM）调节心血管活动的γ-氨基丁酸（GABA）机制。方法：采用3管玻璃微电线作SD大鼠脑内微量注射，观察在RVLM微量注射GABA受体阻断剂后，对心血管活动的紧张性抑制作用的影响。结果：双侧RVLM微量注射GABA_A受体阻断剂4mmol／L荷包牡丹硷20nl（一侧总量80pmol）后，平均动脉压（MAP）升高8．66±0．36kPa（P＜0．01），心率（HR）加快45．3±4．9次／min（P＜0．05）；双侧RVLM微量注射GABA_B受体阻断剂2－OH－S也出现升压及心率加快效应。低剂量组（一侧2－OH－S总量400nmol），MAP升高2．70±0．24kPa（P＜0．01），HR加快16．0±2．1次／min（P＜0．01）。高剂量组（一侧2－OH－S总量1nmol）MAP升高3．01±0．19kPa（P＜0．01），HR加快17．3±1．8次／min（P＜0．05）。结论：RVLM的GABA紧张性抑制作用可通过GABA_A和GABA_B两种受体中介。
OBJECTIVE: To investigate the mechanism of γ-aminobutyric acid (GABA) regulating the cardiovascular activity in the rectocentral ventrolateral region (RVLM). Methods: Three-tube glass micro-electric wire was used to make intracerebral microinjection into SD rats. The effects of GABA receptor blockers injected into RVLM on the inhibition of cardiovascular activity were observed. RESULTS: Bilateral microinjection of GABA_A receptor blockers into the bilateral RVLMs resulted in a mean arterial pressure (MAP) increase of 8.66 ± 0.36 kPa (P <0.01) after 4 mmol / L bicuculline 20 nl (80 pmol on one side) ), Heart rate (HR) accelerated 45.3 ± 4.9 times / min (P <0.05); bilateral RVLM microinjection of GABA_B receptor blocker 2-OH-S also appear to increase blood pressure and heart rate effects. MAP increased 2.70 ± 0.24kPa (P <0.01), HR increased 16.0 ± 2.1 times / min (P <0) .01). MAP increased by 3.01 ± 0.19kPa (P <0.01), HR increased by 17.3 ± 1.8 times / min (P <0. 05). CONCLUSIONS: GABA-mediated inhibition of RVLM can be mediated by both GABA_A and GABA_B receptors.