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目的评价自体骨髓间充质干细胞移植治疗糖尿病足的临床疗效。方法经骨髓动员后抽取自体骨髓,分离单个核细胞,移植入患肢小腿肌肉内,观察治疗前及治疗后3,6个月时糖尿病足疼痛、冷感症状总评分、行走距离评分、经皮氧分压、踝肱指数(ABI)、皮温等客观指标的变化情况,并记录不良事件。结果治疗前及移植后3个月、6个月,自觉疼痛症状评分分别为(2.8±1.7)分、(2.4±1.4)分、(2.1±1.3)分,冷感评分为(2.0±1.0)分、(1.8±0.8)分、(1.6±0.7)分,间歇性跛行评分为(2.4±1.3)分、(2.1±1.2)分、(1.4±1.1)分,治疗后各项评分均明显降低。治疗后皮肤温度及经皮氧分压均明显升高,但治疗后3个月与6个月比较均无显著性差异。结论自体骨髓间充质干细胞移植可以改善糖尿病足临床症状及客观评价指标。
Objective To evaluate the clinical efficacy of autologous bone marrow mesenchymal stem cell transplantation in the treatment of diabetic foot. Methods After mobilization of bone marrow, autologous bone marrow was collected, mononuclear cells were isolated and transplanted into the calf muscles of the affected limbs. The pain of the foot, the symptoms of cold sensation, the walking distance score, the percutaneous Oxygen partial pressure, ankle brachial index (ABI), skin temperature and other objective indicators of changes, and record adverse events. Results Before and 3 months and 6 months after transplantation, the scores of conscious pain were (2.8 ± 1.7) points, (2.4 ± 1.4) points and (2.1 ± 1.3) points respectively. The score of cold sensation was (2.0 ± 1.0) (1.8 ± 0.8) points and (1.6 ± 0.7) points respectively. The scores of intermittent claudication were (2.4 ± 1.3), (2.1 ± 1.2) and (1.4 ± 1.1) points, respectively. . Skin temperature and transcutaneous oxygen pressure were significantly increased after treatment, but there was no significant difference between 3 and 6 months after treatment. Conclusion Autologous bone marrow mesenchymal stem cells transplantation can improve clinical symptoms and objective evaluation of diabetic foot.