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作者用氦离子照射261例眼葡萄膜黑色素瘤。照射剂量50～80Gy/5次/12天,与低LET兆伏X线治疗比较,其相对生物效应值是1.3。261例中42例(16%)发生转移,并从总数中选择40例无转移者作比较分析影响预后的因素。全组随诊3～139个月,5年实际生存(Kaplan-Meier法)80%。8例肿瘤发展,3例经再照射,5例经剜除治疗成功,另34例因治疗的并发症需剜除。261例中222例(85%)保留了眼。在215例有视力记载者中,在环置入前的视力为20/200或更好,85例(40%)在最后随诊中保持了20/200或更好的有用视力,在32例最初视力较20/200为差的病例中,仅3例(90%)在最后随诊中保留了20/400或更好的视力。42例有转
The authors used cerium ions to irradiate 261 cases of uveal melanoma. Irradiation doses of 50 to 80 Gy/5 times/12 days, compared with low LET-MV X-rays, the relative biological effect value was 1.3. Among 261 cases, 42 (16%) had metastases and 40 were selected from the total number. Metastatic patients were compared to analyze the factors that affected the prognosis. The whole group was followed up for 3 to 139 months, and 5 years of actual survival (Kaplan-Meier method) was 80%. Eight tumors developed, three were re-irradiated, five were successfully treated by enucleation, and 34 were treated for complications. Of the 261 cases, 222 (85%) retained the eye. Among the 215 eyes with visual acuity, visual acuity before ring insertion was 20/200 or better, and 85 cases (40%) maintained 20/200 or better visual acuity in the last follow-up, in 32 cases. Of the cases in which the initial visual acuity was worse than 20/200, only 3 (90%) retained 20/400 or better vision at the final follow-up. 42 cases have turn