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应用3种方法计数大肠癌及癌前病变细胞核仁组成区嗜银蛋白(AgNORs),并对AgNORs形态进行观察。结果表明,计数核液中所有银染颗粒的方法,能较好地将大肠肿瘤性病变(腺府、腺癌、腺瘤癌变)与非肿痫性病变(幼年性息肉、炎性息肉等)区别开来,且能较好地将大肠腺癌与腺瘤、癌旁粘腆区别开来,同时大肠腺痫细胞AgNORs计数与其组织民型增生程度及组织学类型有关,反映了重度异型增生与绒毛状腺瘤易于恶变的生物学特性。
Three methods were used to count AgNORs in the colorectal cancer cells of colorectal cancer and precancerous lesions, and the morphology of AgNORs was observed. The results showed that the method of counting all silver-stained particles in nucleus fluid can better treat colorectal neoplastic lesions (carcinogenesis of adenocarcinoma, adenocarcinoma, adenoma) and non-neoplastic lesions (juvenile polyps, inflammatory polyps, etc.). Differentiating and distinguishing colorectal adenocarcinoma from adenoma and paraneoplastic nevus can be achieved. At the same time, AgNORs counts in colorectal adenocarcinoma cells are related to histological type of proliferation and histological type, reflecting severe dysplasia and The vicious adenoma is susceptible to malignant biological characteristics.