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细菌持续性感染日益增多,而抗生素在治疗细菌感染中导致的耐药和复发等副作用已不容忽视。治疗性疫苗能够通过打破机体的免疫耐受,诱导特异性免疫反应,从而达到消除病原体的目的。本文主要针对细菌感染的治疗性疫苗的发展基础、免疫机理和几种已存在的治疗性疫苗研究进展作一综述。
Bacterial persistent infection is increasing, and antibiotics in the treatment of bacterial infections caused by drug resistance and recurrence and other side effects can not be ignored. Therapeutic vaccine can eliminate the pathogen by breaking the immune tolerance of the body and inducing specific immune response. This article mainly reviews the development basis of the therapeutic vaccine for bacterial infection, the immune mechanism and the progress of several existing therapeutic vaccines.