用双盲法把29名近期心肌梗塞患者随机分成安慰剂组(n=14)及阿司匹林组,每日三次,300mg/次(n=15),连续7天。两组均未发现有肾功能改变。与安慰剂组相比,阿司匹林组24小时尿中前列腺素(?)_2(PG(?)_2)的排泄明显被抑制,但尿血管舒缓素活性不变。这些结果与我们以前对类似病人研究的结果相反,那些病人服了苯磺唑酮后,不仅肾功能下降,而且尿中 PG(?)_2及血管舒缓素的排泄也减少了。阿司匹林与苯磺唑酮对尿血管舒缓素活性的这些不同效应可能说明心肌梗塞后早期所观察到的肾功能的不同倾向。 Twenty-nine patients with recent myocardial infarction were randomized to placebo (n = 14) and aspirin using a double-blind method three times daily at 300 mg (n = 15) for 7 consecutive days. Neither group had any change in renal function. Compared with placebo, excretion of prostaglandin (?) _2 (PG (?) _2) in the 24-hour urine of aspirin group was significantly suppressed but urine glibenclamide activity was unchanged. These results contradict our previous findings on similar patients who, after taking benzeazolone, not only lost their kidney function, but their excretion of urinary PG (?) 2 and kallikrein also decreased. These different effects of aspirin and benazepril on urinary glibenclamide activity may indicate different trends in renal function observed early after myocardial infarction.