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目的探讨创伤性体克家兔前列环素、血栓素水平的变化及纳洛酮的治疗作用。方法选择健康家兔40只,随机分为休克组、复苏组、治疗组及假手术组。采用放射免疫分析法分别测定各组休克前及休克后30 min、60 min、120 min、180 min、240 min 血浆血栓素 B_2(TXB_2)及前列环素(6-酮-PGF_(1α))水平。结果治疗组与休克组比较,血浆 TXB_2下降、6-酮-PGF_(1α)增加,差异显著(P<0.05)。复苏组与休克组比较,上述两项观察指标无显著性差异(P>0.05)。治疗组休克前后比较,观察指标无显著性差异,休克组与复苏组有显著性差异。结论创伤性休克血浆 TXB_2明显增高,6-酮-PGF_(1α)水平明显下降,二者比例失调,纳洛酮可干预二者的表达。
Objective To investigate the changes of prostacyclin and thromboxane in traumatic body rabbits and the therapeutic effect of naloxone. Methods Forty healthy rabbits were randomly divided into shock group, resuscitation group, treatment group and sham operation group. Radioimmunoassay was used to measure the levels of thromboxane B 2 (TXB 2) and prostacyclin (6-keto-PGF 1α) in each group before and 30 min, 60 min, 120 min, 180 min and 240 min after shock . Results Compared with the shock group, TXB2 decreased and 6-keto-PGF1a increased in the treatment group and the difference was significant (P <0.05). There was no significant difference between the two resuscitation groups and the shock group (P> 0.05). Before and after treatment in the treatment group, there was no significant difference between the observation index, shock group and recovery group have significant differences. Conclusions The level of TXB2 in traumatic shock is obviously increased, while the level of 6-keto-PGF_ (1α) is obviously decreased. The ratio of the two is imbalanced. Naloxone can interfere with the expression of both.