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应用轮状病毒活疫苗LLR-85株第37代毒种,即LLR-85-37株,接种成人10人,3~6岁小儿21人,6月龄~2岁婴幼儿15人,口服一次,剂量为3×106.0TCIDEA50/ml。所有服苗者均反应轻微,未见发热、腹泻和呕吐等症状。轮状病毒1,2,3,4各型血清中和抗体4倍增长阳性率:3~6岁小儿组(20人)分别为55.0%,50.0%,63.6%和40.0%,对照组13人为0%;6月龄~2岁婴幼儿组(13人)分别为38.5%,69.2%,3%和53.8%,对照组15人为0%。初步观察结果表明LLR-85-37株口服轮状病毒活疫苗是安全、有效的。
Rotavirus live vaccine LLR-85 strains of the 37th generation, LLR-85-37 strain, inoculated 10 adults, 3 to 6 years old in 21 children, 6 months to 2 years old infants and young children 15 oral once , The dose of 3 × 106.0TCIDEA50 / ml. All clothing seedlings were mild reactions, no fever, diarrhea and vomiting and other symptoms. Rotavirus 1, 2, 3, 4 types of serum neutralizing antibodies 4-fold positive rate: 3 to 6 years old pediatric group (20) were 55.0%, 50.0%, 63.6% and 40.0% Control group, 13 were 0%; 6 months to 2 years old infants and young children group (13 people) were 38.5%, 69.2%, 3% and 53.8%, 15% of the control group was 0%. Preliminary observations show that LLR-85-37 strain of oral rotavirus live vaccine is safe and effective.