本工作对 188Re直接标记抗人结肠癌单克隆抗体 CL- 3的方法进行了详细的研究。以抗坏血酸作为抗体的还原剂 ,以 Sn Cl2 -柠檬酸还原 188Re O4 -溶液 ,进行抗体的直接标记。本方法操作简单、方便 ;标记率高 ( >95% )胶体含量小 ( <5% ) ;标记完后不需纯化分离 ;标记物有良好的体外稳定性和较高的免疫活性 ,具有药盒化的前景 This work carried out a detailed study on the method of 188Re direct labeling of anti-human colon cancer monoclonal antibody CL-3. Using ascorbic acid as an antibody reducing agent, SnCl2 - citric acid reduced 188Re O4 - solution for direct labeling of antibodies. The method is simple and convenient; the labeling rate is high (>95%), and the colloidal content is small (<5%); after the labeling, no purification and separation are needed; the label has good in vitro stability and high immunological activity, and has a kit. The prospect of