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目前认为Ｔ淋巴细胞的激活需要两个信号系统，第一信号系统由Ｔ淋巴细胞表面受体（ＴＣＲ）与抗原肽－ＭＨＣ复合物“双重识别”所提供，第二信号系统（共刺激信号）由共刺激分子通过与Ｔ淋巴细胞上相应受体结合而传递［１．２］Ｂ７是产生这种共刺激信号（ｃｏｓｔｉｍｕｌａ?
It is presently believed that activation of T lymphocytes requires two signaling systems, the first signaling system being provided by “dual recognition” of the T lymphocyte surface receptor (TCR) with the antigenic peptide-MHC complex, the second signaling system (co-stimulatory signaling) Binding of co-stimulatory molecules by binding to the corresponding receptors on T lymphocytes [1.2] B7 produces this costimula- tion