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[目的]探讨RECK与血管内皮生长因子(VEGF)、微血管密度(MVD)在非小细胞肺癌(NSCLC)中的表达和相关性。[方法]采用免疫组化SP法检测80例肺癌组织和20例癌旁正常肺组织中RECK、VEGF和MVD的表达水平。[结果]NSCLC中RECK的表达低于癌旁组织(36.25%vs 85.00%,P=0.0001),VEGF(68.75%vs 35.00%,P=0.005)和MVD(20.94±8.76 vs 10.57±4.24,P=0.0001)的表达高于癌旁组织。RECK表达在鳞癌和中、低分化的肿瘤中降低;VEGF在腺癌中表达增高;MVD值在年龄小于60岁患者中增高。VEGF表达与MVD呈正相关;RECK表达与MVD呈负相关。多变量Logistic回归分析显示RECK蛋白表达下调是NSCLC预后不良因素。[结论]RECK、VEGF、MVD表达在NSCLC中有一定相关性,RECK低表达是NSCLC独立不良预后因素。
[Objective] To investigate the expression and correlation of RECK with vascular endothelial growth factor (VEGF) and microvessel density (MVD) in non-small cell lung cancer (NSCLC). [Method] The expression of RECK, VEGF and MVD in 80 cases of lung cancer tissues and 20 cases of adjacent normal lung tissues were detected by immunohistochemical SP method. [Results] The expression of RECK in NSCLC was lower than that in paracancer tissues (36.25% vs 85.00%, P = 0.0001), VEGF (68.75% vs 35.00%, P = 0.005) and MVD (20.94 ± 8.76 vs 10.57 ± 4.24, P = 0.0001) than paracancerous tissues. RECK expression in squamous cell carcinoma and poorly differentiated tumors decreased; VEGF expression in adenocarcinoma increased; MVD in patients younger than 60 years increased. VEGF expression was positively correlated with MVD; RECK expression was negatively correlated with MVD. Multivariate logistic regression analysis showed that the down-regulation of RECK protein expression was a poor prognostic factor for NSCLC. [Conclusion] The expression of RECK, VEGF and MVD in NSCLC has a certain correlation. The low expression of RECK is an independent adverse prognostic factor in NSCLC.