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目的:探讨芩蒿滴鼻液对变应性鼻炎(AR)患者鼻分泌物中P物质(SP)、肿瘤坏死因子-α(TNF-α)、膜联蛋白1(Annexin1)、血管细胞黏附分子-1(VCAM-1)含量的影响。方法:选取我院耳鼻喉科收治的AR患者92例,随机分为对照组和实验组两组。对照组46例患者予曲安奈德鼻喷雾剂治疗,实验组46例患者加用芩蒿滴鼻液治疗。另选取健康体检患者46例。采用酶联免疫法测定各组患者鼻分泌物中TNF-α、Annexin1及VCAM-1的含量,采用放射免疫法测定SP的含量。结果:治疗后,两组鼻分泌物中SP、TNF-α及VCAM-1含量均较治疗前显著下降,Annexin1含量明显升高(P<0.05);与对照组比较,实验组鼻分泌物中SP、TNF-α及VCAM-1含量较低(P<0.05),Annexin1含量较高(P<0.05),实验组临床有效率(91.30%)较对照组(73.91%)显著升高,差异具有统计学意义(P<0.05)。结论:芩蒿滴鼻液能够明显降低AR患者鼻分泌物中SP、TNF-α、VCAM-1的含量,上调Annexin1的含量。
OBJECTIVE: To investigate the effects of QHD on nasal secretions of patients with allergic rhinitis (AR), including substance P (SP), tumor necrosis factor-α (TNF-α), annexin 1, vascular cell adhesion molecule -1 (VCAM-1) content. Methods: 92 cases of AR patients admitted to our department were randomly divided into control group and experimental group. 46 patients in the control group were treated with triamcinolone acetonide nasal spray, and 46 patients in the experimental group were treated with dextromethorphan nasal drops. Another 46 cases of health examination patients. The levels of TNF-α, Annexin1 and VCAM-1 in nasal secretions were determined by enzyme-linked immunosorbent assay. The content of SP was determined by radioimmunoassay. Results: After treatment, the levels of SP, TNF-α and VCAM-1 in nasal secretions decreased significantly compared with those before treatment, and the content of Annexin1 was significantly increased (P <0.05). Compared with the control group, nasal secretions The levels of SP, TNF-α and VCAM-1 were lower (P <0.05) and Annexin1 was higher (P <0.05), and the clinical effective rate (91.30%) in the experimental group was significantly higher than that in the control group (73.91% Statistical significance (P <0.05). Conclusion: SAQD can significantly reduce the content of SP, TNF-α and VCAM-1 in nasal secretions of AR patients and up-regulate the expression of Annexin1.