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目的探讨左炔诺孕酮宫内缓释系统(ING-IUS,即曼月乐)治疗顽固性功能失调性子宫出血患者的临床疗效。方法对65例顽固性功能失调性子宫出血患者放置ING-IUS,放置前、放置后1、3、6、12个月均进行月经量测定、血红蛋白水平检测、经阴道超声检测子宫内膜厚度。结果放置ING-IUS后患者月经量明显减少(P<0.05),血红蛋白水平升高(P<0.05),子宫内膜厚度下降(P<0.05),并持续菲薄状态。结论 ING-IUS治疗顽固性功能失调性子宫出血可以明显减少月经量,纠正贫血、提高血红蛋白水平,可有效抑制子宫内膜增生。
Objective To investigate the clinical efficacy of levonorgestrel-releasing intrauterine system (ING-IUS) in patients with refractory dysfunctional uterine bleeding. Methods 65 patients with intractable dysfunctional uterine bleeding were placed ING-IUS. Before menstruation, 1, 3, 6 and 12 months after implantation, the menstrual volume, hemoglobin level and endometrial thickness were measured by transvaginal sonography. Results After ING-IUS, the menstrual volume was significantly decreased (P <0.05), the hemoglobin level was increased (P <0.05), and the thickness of endometrium was decreased (P <0.05), and continued to be depressed. Conclusion ING-IUS treatment of refractory dysfunctional uterine bleeding can significantly reduce menstrual flow, correct anemia, increase hemoglobin levels, which can effectively inhibit endometrial hyperplasia.