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目的探讨乙型肝炎E抗原HBe Ag阴性慢性乙肝患者前S1抗原检测的临床价值。方法选取我院2009年10月至2011年12月所收治的326例慢性乙型肝炎患者,对HBV血清学标志和前S1抗原血清学检测指标用酶联免疫吸附试验(ELISA)方法来进行检测。结果本组患者中有81例为HBs Ag(+)HBe Ag(-)HBc Ab(+),其中28例(34.6%)为Pre S1Ag阳性;245例为HBs Ag(+),HBe Ag(-),HBe Ab(+),HBc Ab(+),其中113例(46.1%)为Pre S1Ag阳性;本组患者中Pre S1Ag阳性患者为141例(43.3%)。结论 Per S1-Ag能够对HBV的复制与感染情况进行可靠地反映,血清学检测指标效果明显优于HBe Ag。
Objective To investigate the clinical value of pre-S1 antigen detection in patients with hepatitis B E antigen HBeAg-negative chronic hepatitis B. Methods A total of 326 patients with chronic hepatitis B who were admitted to our hospital from October 2009 to December 2011 were enrolled in this study. Serological markers of HBV and pre-S1 antigen were detected by enzyme linked immunosorbent assay (ELISA) . Results Of 81 patients, HBs Ag (+) HBe Ag (-) HBc Ab (+) was detected in 81 patients, of which PreSAg positive was found in 28 patients (34.6% ), HBe Ab (+), and HBc Ab (+), of which 113 cases (46.1%) were positive for Pre S1Ag. PreSAg positive patients were 141 cases (43.3%) in this group. Conclusion Per S1-Ag can reliably reflect the replication and infection of HBV, and the serological detection index is better than that of HBe Ag.