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目的:探讨急性ST段抬高心肌梗死患者溶栓前后白细胞及中性粒细胞计数的意义。方法:将80例急性ST段抬高心肌梗死(STEMI)患者按有无溶栓指征分为溶栓组60例和对照组20例,溶栓组给予溶栓治疗,对照组给予一般治疗。两组于用药前和用药后6 h、12 h、18 h、24 h、28 h各取外周静脉血检测WBC、PMN、CK-MB数值并比较。结果:溶栓组WBC、PMN于用药后12 h达高峰,对照组WBC、PMN于用药后24 h达高峰;溶栓组、对照组WBC、PMN的峰值与各自CK-MB变化呈正相关。结论:溶栓后WBC、PMN骤升,峰值提前,可作为STEMI溶栓再灌注成功的临床指标。
Objective: To investigate the significance of leukocyte and neutrophil count before and after thrombolysis in patients with acute ST-segment elevation myocardial infarction. Methods: Eighty patients with STEMI were divided into thrombolytic group (60 cases) and control group (20 cases) by thrombolytic therapy. Patients in thrombolytic group were given thrombolytic therapy while those in control group were given general treatment. The values of WBC, PMN and CK-MB in peripheral venous blood were measured before and 6 h, 12 h, 18 h, 24 h and 28 h after treatment. Results: WBC and PMN peaked at 12 h after thrombolytic therapy. WBC and PMN peaked at 24 h after treatment in the thrombolytic group. The peak values of WBC and PMN in thrombolysis group and control group were positively correlated with changes of CK-MB. Conclusion: After thrombolysis, the WBC and PMN surge and the peak value advance, which can be used as the clinical index of successful thrombolysis and reperfusion of STEMI.