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目的探讨ICU滞留的慢性重症患者血清降钙素原(PCT)和胱抑素C(Cys-C)的变化特点。方法回顾分析2006年1月-2014年6月医院ICU收治并长期滞留>60d患者的临床资料,统计比较患者入ICU第1、10、20、30、40、50、60天的PCT、Cys C的变化情况。结果年龄(76.32±13.74)岁,滞留ICU时间61d~3.48年,第60天的PCT、Cys C水平低于第1天(P<0.05),但Cys C却持续高于正常水平(>1.09mg/L)。经ICU治疗PCT可完全恢复至正常,但Cys-C经初期下降后,始终保持在偏高于正常值状态,随着ICU治疗时间的延长,有缓慢升高现象。结论慢性重症患者长期滞留ICU,依赖医疗设备和药物维持,能有效控制感染,但是肾脏功能慢性受损,不能完全恢复。
Objective To investigate the changes of serum procalcitonin (PCT) and cystatin C (Cys-C) in chronic severe patients with ICU. Methods From January 2006 to June 2014, the clinical data of patients admitted to ICU for more than 60 days in hospital from January 2006 to June 2014 were retrospectively analyzed. The PCT, Cys C Changes in the situation. Results The age of the patients (76.32 ± 13.74 years) and ICU stay between 61 days and 48 years were significantly lower than that of the first day (P <0.05), but the level of Cys C remained higher than the normal level (> 1.09 mg / L). After ICU treatment of PCT can be completely restored to normal, but Cys-C decreased initially, remained at higher than normal state, with the ICU treatment of time, there is a slow increase in the phenomenon. Conclusion Chronic severe patients stay ICU for a long time, rely on medical equipment and drug maintenance, can effectively control the infection, but chronic renal impairment, can not be completely restored.