Posterior reversible encephalopathy syndrome(PRES)is a clinico-ragiological syndrome presenting with neurological symptoms and characteristic radiologic findings.PRES occurs in the setting of various clinical conditions and requires prompt management of the causative factor for a full recovery.This is a case report of a Crohn’s disease patient who developed PRES syndrome during a complicated post-operative course.In the presence of multiple causative factors,sepsis was considered as the predominant one.After prompt management,the patient recovered with no permanent neurological damage. Posterior reversible encephalopathy syndrome (PRES) is a clinico-ragiological syndrome presenting with neurological symptoms and characteristic radiologic findings. PREs occurs in the setting of various clinical conditions and requires prompt management of the causative factor for a full recovery. This is a case report a Crohn’s disease patient who developed PRES syndrome during a complicated post-operative course. In the presence of multiple causative factors, sepsis was considered as the predominant one. After prompt management management, the patient recovered with no permanent neurological damage.