目的　研制口服结肠定位释放药物的地塞米松 葡聚糖酯及其片剂。方法　通过丁二酸酐搭桥 ,合成地塞米松 葡聚糖酯前体药物 ;紫外光谱、红外光谱、核磁共振谱和质谱法鉴定结构 ;湿法制粒 ,普通压制法制备片剂 ;HPLC法测定体内外地塞米松的含量。结果　合成的地塞米松 葡聚糖酯为目标化合物 ,制得的地塞米松 葡聚糖酯片剂在结肠释放出大部分原药。结论　达到了设计目标 ,有进一步开发研究价值 Objective To develop dexamethasone dextran ester and its tablets for oral colon-targeted drug release. Methods Dexamethasone dextran ester prodrugs were synthesized by succinic anhydride bridging. The structures were identified by UV, IR, The content of dexamethasone. Results The dexamethasone dextran ester synthesized was the target compound, and the dexamethasone dextran ester tablets produced released most of the original drug in the colon. Conclusion reached the design goals, there is further development and research value