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本文分析1987年1月～1991年7月因抗结核药物所致黄疸的50例肺结核病例。其中男40例,女10例,60岁以上占30％。既往有肝病史者占24％,酗酒史占26％。以黄疸、厌食、恶心、腹胀、乏力、肝大、营养不良和腹水为主要表现。黄疸原因以用R类为最多,其次为H、Z、P、1321Th。按肝脏损害情况分为肝实质性黄疸31例和肝内郁积性黄疸19例。多数病人在停药后黄疸指数和转氨酶在3～4周内恢复正常。死亡6例(12％),4例死于肝昏迷,2例死于结核。本文还对抗结核药物性黄疸的处理提出对策。
This article analyzes 50 cases of tuberculosis cases of jaundice caused by antituberculosis drugs from January 1987 to July 1991. Among them, 40 males and 10 females accounted for 30% of those over 60 years old. Past history of liver disease accounted for 24%, alcohol history accounted for 26%. To jaundice, anorexia, nausea, bloating, fatigue, hepatomegaly, malnutrition and ascites as the main performance. Jaundice reasons to use R as the most, followed by H, Z, P, 1321Th. Divided by liver damage in 31 cases of hepatic parenchymal jaundice and hepatic lupus jaundice in 19 cases. The majority of patients in the withdrawal of jaundice index and aminotransferase returned to normal within 3 to 4 weeks. 6 died (12%), 4 died of hepatic coma and 2 died of tuberculosis. This article also countermeasures against the treatment of jaundice drug jaundice.