论文部分内容阅读
制备了具有双相释放特征的醋氯芬酸(AFN)双层控释片(200 mg),并且深入考察了采用两种缓释材料体系达到增强缓释能力的分子机制。采用羟丙甲纤维素(HPMC)和羟丙纤维素(HPC)为主要缓释基质,制备了不同处方的缓释层。在模拟肠液(pH 6.8缓冲液)中考察双层片中AFN的释放行为。通过模拟肠液中聚
A controlled release biphasic (AFN) bilayer controlled release tablet (200 mg) with biphasic release characteristics was prepared and the molecular mechanism of using two sustained-release material systems to enhance sustained release capacity was investigated. Hypochlorite (HPMC) and hydroxypropyl cellulose (HPC) were used as the main sustained release matrix to prepare sustained-release tablets with different prescriptions. AFN release behavior in bilayer tablets was examined in simulated intestinal fluid (pH 6.8 buffer). By simulating intestinal fluid poly