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目的:研究左氟沙星(LVFX)对人体茶碱药物动力学的影响.方法:应用均相酶免疫法.通过测定8名健康志愿者、6名慢性阻塞性肺病患者合用LVFX片前后po氨茶碱片的血药浓度,对合用LVFX前后茶碱药物动力学进行对比.结果:合用LVFX前后除患者组茶碱t_(max)有延长(P<0.01)外,两受试组的K、V_d/F、C_(max)、AUC(0-1)及健康志愿者组的t_(max)均无显著差异(P>0.05).结论:LVFX不影响人体茶碱的分布和清除,临床上可与氨茶碱安全合用.
Objective: To study the effect of levofloxacin (LVFX) on the pharmacokinetics of human theophylline.Methods: The homogeneous enzyme immunoassay was used to determine the pharmacokinetics of levofloxacin in eight healthy volunteers and six patients with chronic obstructive pulmonary disease Theophylline pharmacokinetics were compared before and after treatment with LVFX.Results: Except patients with levofloxacin and levofloxacin before and after treatment, t-max of theophylline was prolonged (P <0.01) There was no significant difference in V_d / F, C_max, AUC (0-1) and t max of healthy volunteers (P> 0.05) .Conclusion: LVFX does not affect the distribution and clearance of human theophylline. Can be safely combined with aminophylline.