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目的分析老年T2DM患者血清性激素结合球蛋白(SHBG)与非酒精性脂肪肝(NAFLD)的相关性。方法 585例年龄>60岁的老年T2DM患者,分为NAFLD组和非NAFLD组,测量身高、体重,检测肝酶、血糖、血脂、FIns及FC-P、SHBG及总睾酮(TT),并计算游离睾酮(FT)。偏相关分析SHBG与各代谢变量间的相关性;Logistic二元回归分析NAFLD的影响因素。结果老年T2DM患者NAFLD组血清SHBG水平(29.0±12.2)nmol/L低于非NAFLD组(45.7±17.8)nmol/L。校正年龄、糖尿病病程、烟酒史、BMI、TG、HDL-C及胰岛素抵抗指数(HOMA-IR)后,随着SHBG四分位数的递增,脂肪肝患病风险呈递减趋势,且进一步在男性校正TT、女性校正FT后,结果仍有统计学意义。结论老年T2DM患者低水平血清SHBG与NAFLD相关。
Objective To analyze the correlation between serum sex hormone binding globulin (SHBG) and non-alcoholic fatty liver (NAFLD) in elderly patients with T2DM. Methods A total of 585 elderly T2DM patients aged> 60 years were divided into NAFLD group and non-NAFLD group. Height and weight, liver enzymes, blood glucose, lipids, FIns and FC-P, SHBG and total testosterone Free testosterone (FT). Partial correlation analysis between SHBG and the metabolic variables; Logistic binary regression analysis of the influencing factors of NAFLD. Results The level of serum SHBG (29.0 ± 12.2) nmol / L in NAFLD group was lower than that in non-NAFLD group (45.7 ± 17.8 nmol / L). After adjustment for age, duration of diabetes, alcohol and tobacco history, BMI, TG, HDL-C and HOMA-IR, the risk of fatty liver showed a decreasing trend with increasing SHBG quartiles, Male correction TT, female correction FT, the results are still statistically significant. Conclusion Low serum SHBG in elderly patients with T2DM is associated with NAFLD.