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破伤风菌苗是将破伤风类毒素 ( TT)包裹在乳酸和乙醇酸多聚物 ( PL GA)形成的微球中 ,其抗原稳定性差。此项研究的目的就是建立新的微粒释放系统 ,在外有 PLGA的囊壁内制备一个含有 TT的稳定核心 ,并在体内外对新系统维持 TT免疫原性的效力进行测定。 作者采用喷雾 -冷凝技
Tetanus vaccine is tetanus toxoid (TT) encapsulated in the microspheres formed by lactic acid and glycolic acid polymer (PL GA), the antigen poor stability. The aim of this study was to establish a new microparticle release system to prepare a stable core containing TT in the outer PLGA wall and to determine the efficacy of the new system in maintaining TT immunogenicity in vivo and in vitro. The author uses spray - condensation technology