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目的:探讨控制性卵巢刺激中,卵泡晚期血清孕酮水平与体外受精、胚胎发育及妊娠结局的关系。方法:2008年1月～2009年4月在遵义医学院附属医院生殖中心接受体外受精助孕的不孕症患者88例,根据hCG注射日血清孕酮水平的不同分为两组,血清孕酮<5.5nmol/L者67例(A组),血清孕酮≥5.5nmol/L者21例(B组),回顾性分析卵泡晚期血清孕酮水平对体外受精、胚胎发育及妊娠结局的影响。结果:A组的总受精率、正常受精率、早期卵裂率、优质胚胎率、胚胎种植率和临床妊娠率明显高于B组(P<0.01)。结论:卵泡晚期血清孕酮水平升高对体外受精和胚胎发育具有负面影响,并导致胚胎种植率和临床妊娠率明显降低。
OBJECTIVE: To investigate the relationship between serum progesterone level in late ovarian follicles and in vitro fertilization, embryonic development and pregnancy outcome in controlled ovarian stimulation. Methods: From January 2008 to April 2009, 88 infertile women receiving in vitro fertilization and fertilization assisted by the Reproductive Center of Affiliated Hospital of Zunyi Medical College were divided into two groups according to the levels of serum progesterone on the day of hCG injection. Serum progesterone Serum progesterone≥5.5nmol / L in 21 cases (group B), 67 cases (group A) with 5.5nmol / L, and the effect of serum progesterone level in late stage of follicle on in vitro fertilization, embryo development and pregnancy outcome were retrospectively analyzed. Results: The total fertilization rate, normal fertilization rate, early cleavage rate, high quality embryo rate, embryo implantation rate and clinical pregnancy rate in group A were significantly higher than those in group B (P <0.01). CONCLUSIONS: Elevated serum progesterone levels in the late follicles have a negative effect on in vitro fertilization and embryo development, leading to a significant reduction in embryo implantation rates and clinical pregnancy rates.