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目的 通过 Ｂｃｌ２ 和 Ｐ５３ 蛋白在胃肠道粘膜相关淋巴组织（ Ｍ Ａ Ｌ Ｔ） 淋巴瘤中的表达，探讨它们与肿瘤恶性程度及预后的关系。方法 收集我院１９９０ 年１ 月到１９９７ 年１２ 月胃肠道 Ｍ Ａ Ｌ Ｔ淋巴瘤２４ 例，行常规 Ｈ Ｅ 和 Ｌ Ｓ Ａ Ｂ 法免疫组化染色， Ｄ Ａ Ｂ 染色，苏木素复染。结果 ２４ 例均为 Ｂ 细胞型 Ｍ Ａ Ｌ Ｔ 淋巴瘤，属低度恶性１６ 例（ 占６６ ．７ ％ ） ，高度恶性８ 例（ 占３３ ．３ ％ ） 。 Ｂｃｌ２ 表达阴性１６例，阳性８ 例。 Ｐ５３ 蛋白表达呈阴性和阳性者各１２ 例。 Ｂｃｌ２ 在低度和高度恶性 Ｍ Ａ Ｌ Ｔ 淋巴瘤中的表达及在不同预后患者中的表达均有差异。 Ｐ５３ 则均无差异。结论 Ｂｃｌ２ 对判断胃肠道 Ｍ Ａ Ｌ Ｔ 淋巴瘤的恶性程度和预测预后均有帮助。 Ｐ５３ 表达与胃肠道 Ｍ Ａ Ｌ Ｔ 淋巴瘤的恶性程度和是否伴有淋巴转移均无关。
Objective To investigate the relationship between the expression of Bcl2 and P53 proteins in gastrointestinal mucosa-associated lymphoid tissue (MLTL) lymphomas and their malignancy and prognosis. Methods Twenty-four cases of gastrointestinal T-lymphoma in the hospital from January 1990 to December 1997 were collected and routine immunohistochemical staining with H E and L S A B methods, D A B staining, and hematoxylin staining. Results All 24 cases were B-cell MATL lymphomas, which belonged to low-grade malignant 16 cases (66.7%) and high-grade malignant 8 cases (33. 3%). Bcl 2 negative expression in 16 cases, positive in 8 cases. Twelve cases were negative and positive for P53 protein expression. The expression of Bcl2 in low-grade and high-malignant MATL lymphomas and their expression in different prognosis patients were different. P53 is no difference. Conclusions Bcl2 is helpful for judging the malignancy and predicting prognosis of gastrointestinal malignancies. The expression of P53 was not associated with the degree of malignancy of the gastrointestinal lymphoblastic lymphoma and whether it was associated with lymphatic metastasis.