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目的探讨原发性皮肤弥漫性大B细胞性淋巴瘤(腿型)(PCDLBCLLT)的临床病理特点。方法回顾性分析17例PCDLBCLLT的临床资料、组织学形态和免疫组化标记。结果 17例PCDLBCLLT的发病年龄为31～86岁,平均64.4岁;其中男性9例,女性8例,男女之比为1.1∶1;主要发生于腿部和躯干部。组织学表现为弥漫分布的肿瘤细胞,以中心母细胞和免疫母细胞为主,核分裂象易见,肿瘤组织不累及表皮。免疫组化:肿瘤细胞表达B细胞相关抗原,bcl-2、MUM1、FOX-P1和bcl-6(+),Ki-67增殖指数为60%～90%。结论 PCDLBCLLT是一种独特类型的大B细胞性淋巴瘤,预后较差。
Objective To investigate the clinicopathological features of primary cutaneous diffuse large B-cell lymphoma (leg type) (PCDLBCLLT). Methods Retrospective analysis of 17 cases of PCDLBCLLT clinical data, histological morphology and immunohistochemical markers. Results The age of onset of PCDLBCLLT in 17 cases was 31-86 years (average 64.4 years). There were 9 males and 8 females, the ratio of male to female was 1.1: 1. The main occurrence occurred in the legs and trunk. Histologically manifested as diffuse distribution of tumor cells to centrocytes and immunoblasts mainly mitochondrial easy to see, the tumor tissue does not affect the epidermis. Immunohistochemistry: The B cells associated antigen, bcl-2, MUM1, FOX-P1 and bcl-6 (+) were expressed in tumor cells, and the proliferation index of Ki-67 was 60% -90%. Conclusion PCDLBCLLT is a unique type of large B-cell lymphoma with poor prognosis.