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利用硼鳌合物的方法,增大6—氟与7—氯取代活性的差异,使哌嗪化选择性取代收率达到82.3％。
The use of boron chelate method to increase the 6 - fluorine and 7 - chlorine substitution activity difference, so that the selectivity of piperazine substitution yield of 82.3%.