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利用大鼠急性脑缺血-再灌注模型,观察了人参皂甙单体Re对急性脑缺血再灌注损伤的保护作用。实验结果表明,Re(10mg/kg)iv能显著地抑制脑缺血-再灌注过程中超氧化物歧化酶的活性下降和脂质过氧化物代谢产物即丙二醛的升高,从而推测Re对脑缺血-再灌注损伤的保护作用可能与抑制氧自由基及脂质过氧化物有关。
Using a rat model of acute cerebral ischemia-reperfusion, the protective effect of ginsenoside Re on acute cerebral ischemia reperfusion injury was observed. The experimental results showed that Re (10 mg/kg)iv significantly inhibited the decrease in the activity of superoxide dismutase and the increase in malondialdehyde, the metabolic product of lipid peroxidation during cerebral ischemia-reperfusion. The protective effect of cerebral ischemia-reperfusion injury may be related to the inhibition of oxygen free radicals and lipid peroxides.