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1980年9月6日至10日在丹麦哥本哈根举行了第12届癫癎国际学术讨论会.会上交流了论文211篇.主要内容集中在癫癎药物的研究,从动物实验、临床药理、对照试验、付作用等方面对多种药物进行了观察.另外,对癫癎的基本机制,发作的内分泌,发作的鉴别诊断,癫癎患者的社会问题和预后,以及脑电记录技术的改进等方面也进行了交流.会议交流的材料有22篇与GABA显效药有关,形成了寻求新型抗癫癎药的一个方向.Meldrum指出新型抗癫癎药的研究必须基于对神经功能的了解,注意力主要集中在疑似或增强主要抑制性递质4-氨酪酸(4-amino-butyric acid)GABA的化合物方面,与此有关的药物有:1.安定类增强GABA受体亲合力;2.巴比妥类作用在膜位置,与氯化Iophore
The 12th International Symposium on Epilepsy was held in Copenhagen, Denmark, from September 6 to September 10, 1980. 211 papers were exchanged, mainly focusing on the study of epileptic drugs, from animal experiments, clinical pharmacology, and control Test, pay the role and so on a variety of drugs were observed.In addition, the basic mechanism of epilepsy, the onset of endocrine, the differential diagnosis of seizures, epilepsy patients with social problems and prognosis, as well as the improvement of EEG recording technology Was also exchanged.The meeting exchanged material with 22 and GABA effective drug, forming a new direction for the search for new anti-epileptic drugs.Meldrum pointed out that the new antiepileptic drug research must be based on the understanding of nerve function, the main attention Drugs that are central to the compounds that are suspected of or enhance the 4-amino-butyric acid GABA, the major inhibitory neurotransmitter, are: 1. Diazepam enhances GABA receptor affinity; 2. Barbiturate Classes act at membrane sites, with chlorinated Iophore