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目的 探讨血管内皮生长因子 (VEGF)在低氧性肺动脉高压发病中的作用。方法 将 30只 Wistar大鼠分为对照组、低氧组和低氧 +苏拉明组 ,以常压低氧复制大鼠肺动脉高压模型 ,采用微导管法测定肺动脉平均压 ,对肺组织切片进行图象分析。结果 经低氧 3周后 ,大鼠形成明显的肺动脉高压、肺小动脉管壁增厚和右心室肥厚 ;经苏拉明处理 ,可明显减轻低氧所致的肺动脉压升高、肺血管壁增厚和右心室肥厚。结论 慢性低氧导致肺动脉高压与 VEGF有密切的关系 ,苏拉明可抑制 VEGF的作用而具有显著预防低氧所致肺动脉高压的效应。
Objective To investigate the role of vascular endothelial growth factor (VEGF) in the pathogenesis of hypoxic pulmonary hypertension. Methods Thirty Wistar rats were divided into control group, hypoxia group and hypoxia + suramin group. The pulmonary hypertension model was induced by normoxia and hypoxia. Pulmonary arterial pressure was measured by microcatheter method. Image analysis Results After 3 weeks of hypoxia, pulmonary hypertension, pulmonary wall thickening and right ventricular hypertrophy were found in rats. Suramin treatment significantly reduced pulmonary arterial pressure induced by hypoxia, Thickening and right ventricular hypertrophy. Conclusions Chronic hypoxia leads to the close relationship between pulmonary hypertension and VEGF. Suramin inhibits the effect of VEGF and significantly prevents pulmonary hypertension induced by hypoxia.