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目的:探讨不同剂量纳洛酮治疗急性酒精中毒的疗效和安全性。方法:128例急性酒精中毒患者随机分为观察组和对照组各64例,两组均对症给予常规治疗,观察组首剂给予纳洛酮2mg静注,然后将2mg纳洛酮加入5%葡萄糖液500ml中静滴维持,而对照组则首剂给予纳洛酮1mg静注,继以1mg加入5%葡萄糖液500ml中持续点滴。结果:两组患者均未出现死亡病倒,亦未见明显不良反应发生;但治疗后观察组患者的意识恢复时间和平稳呼吸恢复时间均明显短于对照组,差异均具有统计学意义(▲P<0.05);治疗后两组患者的血液酒精浓度均有明显下降,且观察组治疗后的血液酒精浓度低于对照组,差异具有统计学意义(★P<0.05)。结论:2mg剂量的纳洛酮静注和静滴维持治疗急性酒精中毒的疗效明显优于1mg的剂量,值得临床应用。
Objective: To investigate the efficacy and safety of different doses of naloxone in the treatment of acute alcoholism. Methods: A total of 128 patients with acute alcoholism were randomly divided into observation group and control group, with 64 cases in each group. All patients in the two groups were given symptomatic treatment. The first dose of naloxone in observation group was intravenously injected with 2 mg naloxone followed by 5% glucose Liquid 500ml intravenous maintenance, while the control group was given the first dose of naloxone 1mg intravenously, followed by 1mg added 5% glucose solution 500ml continued drip. Results: No deaths were found in both groups and no obvious adverse reactions were observed. However, the recovery time of conscious and steady respiratory recovery were significantly shorter in the observation group than in the control group after treatment (P <0.05), the differences were statistically significant P <0.05). After treatment, the blood alcohol levels of both groups were significantly decreased, and the blood alcohol concentration of the observation group was lower than that of the control group (P <0.05). Conclusion: The 2mg dose of naloxone intravenous and intravenous maintenance of acute alcohol poisoning efficacy was significantly better than 1mg dose, worthy of clinical application.