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【目的】探求妊娠期高血压疾病(hypertension disorder complicating pregnancy,HDCP)对其子代神经心理发育的影响。【方法】采用1∶1配对的病例对照研究方法,随访HDCP患者2~5岁子代与正常对照儿童各27人,运用“0~6岁小儿神经心理发育量表”对两组儿童的智能进行评价,并收集两组儿童的生活环境及生活习惯行为等。【结果】HDCP子代在妊娠天数、出生体重及出生身长方面均低于正常儿童(P<0.05)。在神经心理发育方面,显示出HD-CP子代在语言和社交两个维度上的智能以及发育商方面显著低于正常对照儿童(P<0.05)。在生活环境方面,社交行为智能发育与被动吸烟呈负相关,而与常住人口呈正相关(P<0.05)。在生活行为方式方面,社交行为智能发育和发育商与每日户外活动时间、喜欢与同龄儿童交流呈正相关(P<0.05),而与每日观看电视/电脑的时间呈负相关(P<0.05)。【结论】HDCP患者生活环境和生活行为方式对儿童的神经心理发育有影响。
【Objective】 To investigate the effect of HDCP on the neuropsychological development of offspring. 【Methods】 A 1: 1 paired case-control study was conducted. The HDCP patients were followed up for 27 children between 2 to 5 years of age and normal controls respectively. The neuropsychological developmental scale of children aged 0 to 6 years Of the intelligence evaluation, and to collect two groups of children’s living environment and lifestyle habits. 【Results】 HDCP progeny were lower than normal children in gestational days, birth weight and birth length (P <0.05). In neuropsychological development, HD-CP progeny were shown to be significantly lower in intelligence and developmental dimensions in both linguistic and social dimensions as compared to normal controls (P <0.05). In the aspect of living environment, the social behavior intelligence development was negatively correlated with passive smoking, but positively correlated with the resident population (P <0.05). In terms of lifestyle behaviors, the number of social behavior developmental and developmental developers and daily outdoor activities like the exchange of children of the same age positively (P <0.05), but negatively correlated with the daily viewing time of TV / computer (P <0.05 ). 【Conclusion】 HDCP patients living environment and lifestyle behavior have an impact on children’s neuropsychological development.