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目的 回顾性分析Ⅰ、Ⅱ期胃原发非霍奇金淋巴瘤病例 ,探讨手术、放射治疗和化疗在其治疗中的地位。方法 经手术后病理确诊为Ⅰ、Ⅱ期胃原发非霍奇金淋巴瘤 84例 ,其中 43例接受术后放射治疗和化疗 ,2 5例仅接受术后放射治疗和 8例仅接受术后化疗。放射治疗采用6 0 Co或 6、18MVX射线。化疗采用CHOP、COP、COPP、COMP和COBDP方案。生存率采用Kaplan Meier法计算及Logrank检验 ,多因素分析采用Cox回归模型。结果 全组病例 3、5年生存率分别为 82 .1%和 78.6 % ,其中Ⅰ期和Ⅱ期 3、5年生存率分别为 98.0 %和 5 8.8% ,96 .0 %和 5 2 .9% ,P =0 .0 0 3。单因素和多因素分析显示临床分期和放射治疗与否是独立预后因素。结论 手术在Ⅰ、Ⅱ期胃原发非霍奇金淋巴瘤的治疗中占主导地位 ,术后放射治疗能提高患者的生存率 ,而化疗作用不能肯定
Objective To retrospectively analyze cases of stage I and II primary gastric non-Hodgkin’s lymphomas and to explore the role of surgery, radiation therapy, and chemotherapy in their treatment. Methods Eighty-four patients with stage I and II primary gastric non-Hodgkin’s lymphoma were confirmed by pathology after surgery. Among them, 43 cases received postoperative radiotherapy and chemotherapy, 25 cases received postoperative radiotherapy and 8 cases received postoperative only. Chemotherapy. Radiation therapy uses 60 Co or 6, 18 MV X-rays. CHOP, COP, COPP, COMP, and COBDP regimens were used for chemotherapy. The survival rate was calculated using the Kaplan Meier method and Logrank test. Multivariate analysis was performed using the Cox regression model. Results The 3-year and 5-year survival rates of the whole group were 82.1% and 78.6%, respectively. The 3-year and 5-year survival rates of stage I and II were 98.0 % and 58.8% respectively, 96.0% and 52.9%. %, P =0.0 0 3. Univariate and multivariate analysis showed that clinical staging and radiotherapy were independent prognostic factors. Conclusions Surgery is the leading treatment for primary gastric non-Hodgkin’s lymphoma in stage I and II. Postoperative radiotherapy can improve the survival rate of patients, but the effect of chemotherapy can not be affirmed.