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目的:观察肠内营养加四味参芪口服液管饲对食管癌术后患者肠道功能及免疫功能的影响。方法:选择我院于2008年1月至2012年3月期间接受食管癌根治术的84例患者作为研究对象,将84例患者按随机表法分成两组各42例,治疗组行食管癌根治术后肠内营养加四味参芪口服液管饲(EN),对照组行食管癌根治术后静脉营养(PN)。分别观察术后肛门排气、排便时间和肠鸣音正常的时间,术前、术后7天、术后14天监测外周血T淋巴细胞亚群(CD3,CD4,CD8,CD4/CD8)、B淋巴细胞、NK细胞活性。结果:两组患者均按计划完成治疗。治疗组术后平均肠道功能恢复时间12~24小时,对照组平均肠道功能恢复时间36~72小时,治疗组肠道功能恢复时间明显优于对照组(P<0.05)。对照组和治疗组术后7天外周血T淋巴细胞亚群(CD3,CD4,CD8,CD4/CD8)、B淋巴细胞、NK细胞活性均明显下降,两者之间无明显差异(P>0.05)。治疗组术后14天恢复到术前水平;而对照组术后14天有所恢复,但仍明显低于术前水平,两者之间有明显差异(P<0.05)。结论:肠内营养加四味参芪口服液管饲对食管癌术后患者的肠道功能和免疫功能有良好的调节作用,使得患者的肠道功能和免疫功能迅速从手术打击中恢复,尽快进入内科综合治疗和康复治疗阶段。
Objective: To observe the effects of enteral nutrition plus four-flavor Shenqi oral gavage on intestinal function and immune function in postoperative esophageal cancer patients. Methods: Eighty-four patients undergoing esophageal cancer radical mastectomy from January 2008 to March 2012 in our hospital were divided into two groups (n = 42) according to the random table method. 84 patients underwent radical esophagectomy After enteral nutrition plus four flavor Shenqi oral liquid tube feeding (EN), the control group underwent esophagectomy after radical prostatectomy (PN). Peripheral blood T lymphocyte subsets (CD3, CD4, CD8, CD4 / CD8) were observed before operation, 7 days after operation and 14 days after operation respectively. B lymphocytes, NK cell activity. Results: Both groups completed the treatment according to plan. The average recovery time of intestinal function in treatment group was 12-24 hours, while the average recovery time of intestinal function in control group was 36-72 hours. The recovery time of intestinal function in treatment group was significantly better than that in control group (P <0.05). The activity of T lymphocyte subsets (CD3, CD4, CD8, CD4 / CD8), B lymphocytes and NK cells in the control group and the treatment group decreased significantly at 7 days after operation, with no significant difference between the two groups (P> 0.05 ). The treatment group returned to the preoperative level 14 days after operation, while the control group recovered 14 days after operation, but still lower than the preoperative level. There was a significant difference between the two groups (P <0.05). Conclusion: Enteral nutrition combined with Siwei and Shenqi oral liquid tube feeding has good regulation on intestinal function and immune function in postoperative patients with esophageal cancer, which makes the intestinal function and immune function of patients recover quickly from surgical operation. Into the comprehensive medical treatment and rehabilitation treatment phase.