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变应原标准化的目的在于提高特异性诊断和治疗的可靠性和安全性.不同国家对变应原标准化的要求可能不同.例如.一方面可用一种特异的方法标定变应原浸液的效价,另一方面亦可测定该浸液中某些已知变应原分子的含量,或两者兼顾.另外.还可测定某些变应原分子的最低耐受量或最高含量以及所含各特异性组分之间的比率.另一个敏感的问题是如何确定变应原的活性单位.最近有人建议用相应组胺释放量或皮肤试验反应强度等体内试验或体外测定相应特异性IgE抗体来确定活性单位.但这些方法都依赖于所选择的病人,某一种或几种变应原成分的绝对含量,或仅仅是一种入为的规定.
The purpose of allergen standardization is to improve the reliability and safety of specific diagnosis and treatment.Different countries may have different requirements for the standardization of allergens.For example, on the one hand, a specific method can be used to calibrate the effect of allergen infusion The price, on the other hand can also be measured in the immersion in some of the known allergen molecules, or both. In addition can also be measured for some allergen molecules minimum tolerated or maximum content and contained The ratio between specific components Another sensitive issue is how to determine the allergen activity units.It has recently been suggested that the corresponding histamine release or skin test response intensity and other in vivo tests or in vitro determination of the corresponding specific IgE antibodies But these methods are dependent on the patient selected, the absolute content of one or more allergen components, or just a requirement.