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作者比较了部分生物碱对大鼠肝内药物代谢酶系活性的影响。实验动物分别腹腔注射用生理盐水新鲜配制的马钱子碱(2mg/kg)、秋水仙碱(1mg/kg)、吐根碱(4mg/kg)、血根碱(10mg/kg)、东莨菪碱(2mg/kg)溶液和用玉米油配制的波尔定碱(boldine)(5mg/kg)、烟碱(4mg/kg)、利血平(2.5mg/kg)、茄碱(10mg/kg)和士的宁(2mg/kg)悬液,另设生理盐水和玉米油两组为对照。连续给药三天后测定戊巴比妥的睡眠时间,发现波尔定碱、秋水仙碱、吐根碱、血根碱和茄碱是微粒体酶抑
The authors compared the effects of some alkaloids on the activity of drug-metabolizing enzymes in the liver of rats. The experimental animals were injected intraperitoneally with brucine (2mg / kg), colchicine (1mg / kg), emetine (4mg / kg), sanguinarine (10mg / kg) and scopolamine (5mg / kg), nicotine (4mg / kg), reserpine (2.5mg / kg), solanine (10mg / kg) and corn oil Strychnine (2mg / kg) suspension, another set of saline and corn oil two groups as a control. Three consecutive days after the administration of pentobarbital determination of sleep time and found that polidine, colchicine, emetine, sanguinarine and solanine microsomal enzyme inhibition