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目的探讨妊娠合并卵巢癌患者行保留生育功能治疗对其妊娠结果的影响及安全性。方法回顾性分析2013年6月至2014年6月间山东省临朐县人民医院收治的40例妊娠合并卵巢癌患者的临床资料,观察并记录患者卵巢肿瘤首次确诊时间、方式、病理类型、处理方式及妊娠结果。结果妊娠合并卵巢癌患者首次确诊时间在孕晚期的百分率明显高于孕前、孕早期、孕中期,差异有统计学意义(P<0.05)。妊娠合并卵巢癌患者确诊发现方式为超声检查的显著高于妇科检查及剖宫产手术,差异有统计学意义(P<0.05)。妊娠合并卵巢癌患者成熟畸胎瘤发生率显著高于卵巢瘤样病变、卵巢巧克力囊肿、黏液性囊肿、卵巢冠囊肿、浆液性囊腺瘤,差异有统计学意义(P<0.05)。妊娠合并卵巢癌患者处理例数中剖宫产显著高于自然分娩、流产、早产,差异有统计学意义(P<0.05)。妊娠合并卵巢癌患者自然分娩、早产、剖宫产术胎儿生存率相近,差异无统计学意义(P>0.05)。妊娠合并卵巢癌患者自然分娩、早产、流产、剖宫产术胎儿生存率相近,差异无统计学意义(P>0.05)。结论对于妊娠合并卵巢癌患者于剖宫产期间实施保留生育功能治疗可获得显著疗效,胎儿及产妇存活率较高,安全性较为肯定,值得推广。
Objective To investigate the effect and safety of the treatment of pregnant women with pregnancy associated with ovarian cancer on the pregnancy outcome. Methods The clinical data of 40 patients with pregnancy complicated with ovarian cancer who were treated in Lintao County People’s Hospital of Shandong Province from June 2013 to June 2014 were retrospectively analyzed. The time, mode, pathological type and treatment of ovarian tumor were observed and recorded And pregnancy results. Results The percentage of the first diagnosis of pregnancy complicated with ovarian cancer in the third trimester of pregnancy was significantly higher than that before pregnancy, early pregnancy and second trimester, the difference was statistically significant (P <0.05). The diagnosis of ovarian cancer in patients with pregnancy found that the way for ultrasound was significantly higher than gynecological examination and cesarean section, the difference was statistically significant (P <0.05). The incidence of mature teratoma in patients with pregnancy complicated with ovarian cancer was significantly higher than that of ovarian tumor-like lesions, ovarian chocolate cyst, mucinous cyst, ovarian canine cyst and serous cystadenoma (P <0.05). Cesarean section in patients with pregnancy complicated with ovarian cancer was significantly higher than those in spontaneous labor, abortion and premature delivery (P <0.05). Pregnancy with ovarian cancer in patients with natural childbirth, premature delivery, cesarean section fetus survival rate was similar, the difference was not statistically significant (P> 0.05). Pregnancy with ovarian cancer patients with natural childbirth, premature birth, abortion, cesarean section fetus survival rate was similar, the difference was not statistically significant (P> 0.05). Conclusion The treatment of pregnant women with ovarian cancer in the cesarean section to retain the reproductive function of the treatment of significant effect can be obtained, fetus and maternal survival rate is higher, the safety is more certain, it is worth promoting.