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目的:探讨胎盘生长因子(PlGF)及其受体血管内皮生长因子受体-1(Flt-1)与胃癌血管形成和临床病理特点的关系。方法:应用免疫组织化学染色法检测84例胃癌组织及20例正常胃组织中的PlGF和Flt-1,并计算以CD34为标志的微血管密度(MVD),分析其与胃癌临床病理因素及预后的关系。结果:PlGF和Flt-1在胃癌组织中的表达均高于正常胃组织(P<0.05)。PlGF表达与胃癌的组织学分化程度、浸润深度、Borrmann分型、淋巴结转移有关(P<0.05);Flt-1表达与胃癌的浸润深度、Borrmann分型有关(P<0.05);MVD与肿瘤浸润深度、Borrmann分型、淋巴结转移有关(P<0.05)。PlGF与Flt-1表达阳性患者的5年存活率分别为45.5%、40.4%。浸润深度、Flt-1阳性表达为影响胃癌患者生存的独立预后因素。结论:PlGF/Flt-1通路可能在胃肿瘤血管发生及发展过程中起重要作用,从而影响胃癌的进展及预后。
Objective: To investigate the relationship between placental growth factor (PlGF) and its receptor vascular endothelial growth factor receptor-1 (Flt-1) and angiogenesis and clinicopathological features of gastric cancer. Methods: The expressions of PlGF and Flt-1 in 84 gastric cancer tissues and 20 normal gastric tissues were detected by immunohistochemical staining, and the microvessel density (MVD) marked by CD34 was calculated. The relationship between them and clinicopathological factors and prognosis of gastric cancer relationship. Results: The expressions of PlGF and Flt-1 in gastric cancer tissues were significantly higher than those in normal gastric tissues (P <0.05). The expression of PlGF was correlated with the degree of histological differentiation, depth of invasion, Borrmann type and lymph node metastasis (P <0.05). The expression of Flt-1 was correlated with the depth of invasion and Borrmann type (P <0.05) Depth, Borrmann classification, lymph node metastasis (P <0.05). The 5-year survival rates of patients with positive expression of PlGF and Flt-1 were 45.5% and 40.4%, respectively. Invasion depth, Flt-1 positive expression as an independent prognostic factor for survival of patients with gastric cancer. Conclusion: PlGF / Flt-1 pathway may play an important role in angiogenesis and development of gastric tumor, which may affect the progress and prognosis of gastric cancer.