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目的:研究子宫内膜病变的不同发展阶段细胞增殖核蛋白和葡萄糖转运蛋白Ι在病变组织中的表达,探讨子宫内膜癌细胞生物学行为的分子学基础。方法:收集珠海市妇幼保健院近年子宫内膜癌标本档案蜡块及同期子宫内膜标本档案蜡块为研究对象,根据诊断标准和病理分级分组,观察不同阶段病变组织细胞中GLUTs和PCNA的表达。结果:细胞增殖核蛋白和葡萄糖转运蛋白与子宫内膜病变的程度成正相关(r1=0.85;r2=0.82),简单增生组织细胞中不表达或少表达,子宫内膜癌组织中高表达(P<0.05)。结论:细胞增殖核蛋白和葡萄糖转运蛋白是子宫内膜病变诊断的可靠依据,可为其提供治疗方案的选择、评定治疗效果和评估预后。
OBJECTIVE: To study the expression of proliferating cell nuclear protein and glucose transporter 1 in diseased tissues at different stages of endometrial lesion, and to explore the molecular basis of the biological behavior of endometrial cancer cells. Methods: In recent years, Zhuhai Municipal Maternal and Child Health Hospital collection of endometrial cancer specimens archives of wax and endometrial archival wax arch as the object of study, according to diagnostic criteria and pathological grading group, observe the different stages of diseased tissue cells GLUTs and PCNA expression . Results: There was a positive correlation between cell proliferating nuclear protein and glucose transporter protein and the degree of endometrial lesions (r1 = 0.85; r2 = 0.82), no or less expression in simple hyperplasia cells and high expression in endometrial carcinoma (P < 0.05). CONCLUSION: Cell proliferating nuclear protein and glucose transporter are the reliable basis for the diagnosis of endometrial lesions. They can provide a choice of treatment options, evaluate the therapeutic effect and evaluate the prognosis.