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目的探讨糖尿病患者尿单核细胞趋化蛋白1(MCP-1)和血细胞间黏附分子1(ICAM-1)水平与糖尿病肾病的发生发展及炎症反应的关系。方法将90例糖尿病患者按尿白蛋白排泄率(UAER)分为正常白蛋白尿(NA)组、微量白蛋白尿(MA)组、临床白蛋白尿(CA)组,分别测定血、尿MCP-1与血sICAM-1和高敏C反应蛋白(hsC-RP),并与30名健康对照组(NC)比较。结果 NC、NA、MA、CA组间的血MCP-1水平差异无统计学意义(P>0.05),尿MCP-1及血sICAM-1水平逐渐升高,差异有统计学意义(P<0.05或P<0.01);尿MCP1及血sICAM-1水平与UAER均呈正相关(r=0.891,P<0.01;r=0.583,P<0.01);尿MCP-1及血sICAM-1水平与血hsC-RP均呈正相关(r=0.723,P<0.01;r=0.625,P<0.01)。结论尿MCP-1及血sICAM-1水平与糖尿病肾病炎症反应程度有一定关系,可作为肾脏损害程度及其发生发展的判断指标。
Objective To investigate the relationship between the levels of monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule-1 (ICAM-1) in diabetic patients and the occurrence and development of diabetic nephropathy and inflammatory reaction. Methods 90 cases of diabetic patients were divided into normal albuminuria (NA) group, microalbuminuria (MA) group and clinical albuminuria (CA) group according to urinary albumin excretion rate (UAER) -1 and blood sICAM-1 and high-sensitivity C-reactive protein (hsC-RP), and compared with 30 healthy control group (NC). Results There was no significant difference in serum MCP-1 levels between NC, NA, MA and CA groups (P> 0.05), and the levels of urinary MCP-1 and sICAM-1 in urine increased gradually (P <0.01 or P <0.01). Urinary MCP1 and sICAM-1 levels were positively correlated with UAER (r = 0.891, P <0.01; r = 0.583, -RP were positively correlated (r = 0.723, P <0.01; r = 0.625, P <0.01). Conclusions The levels of urinary MCP-1 and sICAM-1 in blood are related to the degree of inflammatory reaction in diabetic nephropathy, which can be used as the index of judging the degree of renal damage and its occurrence and development.