细胞凋亡异常与肿瘤的发生存在密切的关系。通过靶向细胞凋亡通路中的关键分子,诱导肿瘤细胞凋亡,成为肿瘤分子治疗的一个热点和方向。本文就细胞凋亡的分子机制及针对凋亡通路中的关键调控分子为靶点的抗肿瘤研究进展进行综述。 Abnormal apoptosis and tumor incidence are closely related. By targeting key molecules in the apoptotic pathway, inducing apoptosis of tumor cells has become a hot spot and direction of tumor molecular therapy. This review summarizes the molecular mechanisms of apoptosis and the progress of antitumor research targeting key regulatory molecules in apoptotic pathways.