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目的:探讨改良超长降调节方案对卵巢低反应患者体外受精-胚胎移植结局的影响。方法:回顾性分析华中科技大学同济医学院附属同济医院生殖医学中心86例行体外受精-胚胎移植术的卵巢低反应患者,其中33例采用短方案(A组),53例采用改良超长降调节方案(B组)。比较两组的超排卵天数及Gn用量、HCG日血清激素水平、获卵数、优质胚胎率、临床妊娠率和周期取消率等。结果:两组Gn启动剂量、HCG日E2值、HCG日子宫内膜厚度、获卵数及移植胚胎数比较无统计学差异(P>0.05);优质胚胎率及周期取消率,B组较A组高,但无统计学差异(P>0.05);Gn天数B组较A组长(P<0.05);临床妊娠率B组较A组高(P<0.05)。结论:改良超长降调节方案对于卵巢低反应患者是一种有效的促排卵方案。
OBJECTIVE: To investigate the effect of modified super-long-shortening regimen on outcomes of in vitro fertilization-embryo transfer in patients with low ovarian response. Methods: A retrospective analysis of 86 patients with ovarian response undergoing in vitro fertilization-embryo transfer was performed in Reproductive Medicine Center, Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology. Among them, 33 patients were treated with short protocol (group A) and 53 patients with modified ultra- Regulatory program (group B). The days of superovulation and the amount of Gn, HCG level of serum hormone, the number of oocytes retrieved, the rate of high quality embryo, clinical pregnancy rate and cycle cancellation rate were compared between the two groups. Results: There was no significant difference in Gn activation dose, E2 value on HCG day, endometrial thickness on HCG day, number of oocytes retrieved and number of embryos transferred (P> 0.05) (P> 0.05). The Gn days in group B were longer than those in group A (P <0.05). The clinical pregnancy rate in group B was higher than that in group A (P <0.05). Conclusion: The modified regimen of overexpression is an effective ovulation induction regimen for patients with low ovarian response.