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锑剂在治疗血吸虫病中的死亡事故,主要由于心律紊乱,临床上表现为莫-阿-斯(Morgagni-Adams-Stokes)氏综合征。目前大多数认为,锑剂治疗中偶然发生的毒性心律紊乱可能由于锑剂对心肌本身及植物神经复合作用的结果。关于这种毒性心律紊乱发病学中的神经机制,近年来已积累了许多研究资料;至于锑剂对心肌的直接作用,以及其对心肌基本特性的影响方面则仍然知道得很少。
Antimony agents in the treatment of schistosomiasis deaths, mainly due to heart rhythm disorders, clinically manifested as M - M - Ag - Adams-Stokes syndrome. At present, most believe that the accidental occurrence of toxic arrhythmia in the treatment of antimony agents may be due to the complexation of the antimony agent with the myocardium itself and autonomic nerves. Numerous studies have been accumulated on the neural mechanisms in the pathogenesis of this toxic arrhythmia, and there is still little to know about the direct effect of antimony agents on myocardium and its impact on the basic characteristics of the myocardium.