论文部分内容阅读
目的:通过了解2009年平顶山市手足口病的病原学特征,为手足口病防治工作提供科学依据。方法:收集2009年3～12月468例手足口病患儿的粪便、血清、咽拭子、疱疹液、脑脊液标本共764份,用RT-PCR进行检测。结果:468例被检测患儿中318例为肠道病毒阳性,阳性率为67.95%,其中EV71感染最高,占37.18%。764份标本中有452份检测出肠道病毒阳性,总阳性率为59.16%,其中粪便标本阳性检出率最高,为67.65%。重症患儿肠道病毒阳性检出率为76.39%,EV71阳性116例,占70.30%。男性发病多于女性,男女比为1.75∶1,男性肠道病毒阳性检出率高于女性(χ2=7.7454,P=0.0054)。肠道病毒阳性病例主要集中4岁以下儿童,占93.36%。结论:平顶山市2009年儿童手足口病病原体以EV71为主,粪便标本中PCR阳性率检出较高。
Objective: To understand the etiological characteristics of HFMD in Pingdingshan in 2009 and provide a scientific basis for the prevention and treatment of HFMD. Methods: A total of 764 specimens of stool, serum, throat swab, herpes fluid and cerebrospinal fluid of 468 hand-foot-mouth disease patients from March to December 2009 were collected and detected by RT-PCR. Results: Of the 468 children tested, 318 cases were positive for enterovirus, the positive rate was 67.95%, of which the highest was EV71, accounting for 37.18%. Of the 764 samples, 452 were positive for enterovirus detection, with a total positive rate of 59.16%. The highest positive rate of stool samples was 67.65%. The positive rate of enterovirus in critically ill children was 76.39%, and the positive rate of EV71 was 116, accounting for 70.30%. Male incidence of more than women, male to female ratio was 1.75: 1, male enterovirus positive rate was higher than female (χ2 = 7.7454, P = 0.0054). Enterovirus positive cases mainly focus on children under 4 years of age, accounting for 93.36%. Conclusion: The pathogens of hand, foot and mouth disease in children in Pingdingshan were mainly EV71 in 2009, and the positive rate of PCR was higher in stool samples.