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目的:比较CDK4及MDM2在不同危险分层腹膜后脂肪肉瘤(RPLS)中的表达。方法:选择我院普外科手术切除的原发性及复发性RPLS 129例(共151例次标本),均经常规术后病理检查确诊并行CDK4、MDM2等免疫组化检查,比较CDK4、MDM2在不同危险分层RPLS中的阳性表达情况。结果:CDK4在高危组阳性表达率达98.0%,显著高于低危组的70.4%(P<0.05);与中危组的80.8%比较,差异不显著(P>0.05)。MDM2在高危组阳性表达率为93.8%,显著高于低危组的66.7%和中危组的61.5%(P<0.05)。CDK4和MDM2在高危组不同病理分型阳性表达率均较高,但组间差异不显著(P>0.05)。结论:CDK4、MDM2在高危RPLS阳性率表达更高,对RPLS预后有一定参考价值。
Objective: To compare the expression of CDK4 and MDM2 in different risk stratified retroperitoneal liposarcoma (RPLS). Methods: A total of 129 cases of primary and recurrent RPLS were selected from our hospital for routine surgical resection. All of them were routinely confirmed by postoperative pathology and immunohistochemically tested by CDK4 and MDM2. CDK4 and MDM2 were compared between the two groups Different risk stratification RPLS in the positive expression. Results: The positive expression rate of CDK4 in high risk group was 98.0%, which was significantly higher than that in low risk group (70.4%, P <0.05). Compared with 80.8% in intermediate risk group, the difference was not significant (P> 0.05). The positive expression rate of MDM2 in high risk group was 93.8%, significantly higher than 66.7% in low risk group and 61.5% in intermediate risk group (P <0.05). The positive rates of CDK4 and MDM2 were higher in different pathological types of high risk group, but there was no significant difference between the two groups (P> 0.05). Conclusion: The positive rates of CDK4 and MDM2 in high-risk RPLS are higher than those in normal RPLS, which may provide some reference value for the prognosis of RPLS.