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肉毒毒素（Ｂｏｔｏｘ）局部注射已成为各种肌张力障碍的首选治疗。我们用ＢｏｔｏｘＡ治疗肌张力障碍性疾病２６２例，有效率９９．２３％。本组男性８９例，女性１７３例。年龄１０～７１岁，平均５１．２岁；病程２月～３８年，平均３．６年；随访２～３６月，平均２１．６月。ＢｏｔｏｘＡ分别稀释成２５Ｕ／ｍｌ、２７．５Ｕ／ｍｌ和３０．５Ｕ／ｍｌ三种浓度，随机分别给病人注射，观察疗效与浓度的关系。注射前后检查ＥＭＧ，以探讨２点间最佳距离。结果表明：小块肌肉和大块肌肉的最佳浓度分别是２７．５Ｕ／ｍｌ和３０．５Ｕ／ｍｌ；最佳距离分别是１．５ｃｍ和２ｃｍ～３ｃｍ。
Botox topical injection has become the treatment of choice for various dystonias. We use BotoxA treatment of dystonia disease in 262 cases, the effective rate of 99.23%. The group of 89 males and 173 females. Aged 10 to 71 years, mean 51.2 years; duration of February to 38 years, an average of 3.6 years; 2 to 36 months of follow-up, an average of 21.6 months. BotoxA were diluted to 25U / ml, 27.5U / ml and 30.5U / ml three concentrations, were randomly assigned to patients, to observe the relationship between efficacy and concentration. Check EMG before and after injection to explore the best distance between two points. The results showed that the best concentration of small muscle and large muscle was 27.5U / ml and 30.5U / ml respectively; the best distance was 1.5cm and 2cm ~ 3cm respectively.