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Angew.Chem.Int.Ed.2015,54,1608~1611路易斯酸催化α-重氮酯和羰基化合物的同系化反应是合成β-酮酸酯化合物的有效方法,反应经历亲核加成、重排历程,其区域选择性复杂,立体选择性控制困难.以醛、环酮以及活化酮等羰基化合物为亲电试剂的不对称催化反应已有成功报道,仅有的一例简单酮与α-重氮酯的反应,在手性双氮氧-钪配合物催化剂条件下得到了α-胺化产物.四川大学化学学院冯小明、李伟等基于他们在这一领域的系统研究,设计了分子内的简单酮与α-重氮酯的不对称同
Angew. Chem. Int. Ed. 2015, 54, 1608-1611 The Lewis acid catalyzes the homologation of α-diazo esters with carbonyl compounds as an efficient method for the synthesis of β-keto acid ester compounds. The reaction undergoes nucleophilic addition, Row process, the complexity of the regional selectivity, stereoselective control difficulties with aldehydes, cyclic ketones and ketones and other carbonyl compounds as the electrophile asymmetric catalytic reaction has been successfully reported, only one case of simple ketone and α-heavy Nitrogen esters obtained under the conditions of chiral diazotization - scandium complex catalyst α-amination products.Sichuan University Chemistry School Feng Xiaoming, Li Wei, etc. based on their systematic research in this area, the design of the intramolecular The simple ketone and α-diazo ester asymmetry with