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目的观察愈伤Ⅰ号小鼠灌胃的安全性,为临床安全用药提供依据。方法用愈伤Ⅰ号或饮用水,以最大给药浓度及可承受的最大体积对小鼠一次性灌胃,3天后对比存活情况;并采用一日最大给药量灌胃,7天后对比愈伤Ⅰ号与饮用水灌胃后,小鼠体重和食量、外表行动、反应活动、饮水量及大小便情况。将小鼠最大灌胃量通过公式转换为成人每日用量。结果愈伤Ⅰ号超声雾化剂灌胃的小鼠全部存活,具有安全性;上述观察指标两组对比,差异不明显(P>0.05);小鼠一日最大给药量为3.36g,经换算相当于成人临床日用量的133倍。结论愈伤Ⅰ号超声雾化剂使用比较安全,可用于临床研究及治疗。
Objective To observe the safety of intragastric administration of callus Ⅰ mice and provide evidence for clinical safety. Methods Callus Ⅰ or drinking water, the maximum dose concentration and the maximum tolerable volume of mice once gavage, 3 days after the comparison of survival; and the maximum daily dose of gavage, 7 days after the comparison of more Injury Ⅰ and drinking water after gavage, the mouse body weight and food intake, the appearance of action, reaction activity, water intake and urine situation. The maximum intragastric dose of mice was converted to the daily dosage of adult by formula. Results Callus No. 1 ultrasonic atomizing agent gavage mice all survived, with safety; the above indicators were compared between the two groups, the difference was not significant (P> 0.05); the maximum daily dose of mice was 3.36g, Conversion equivalent to 133 times the daily amount of adult clinical. Conclusion Callus Ⅰ ultrasonic atomizing agent is safe to use and can be used in clinical research and treatment.