色素上皮细胞衍生因子 (pigm ent epithelium- derived factor,PEDF)是最先在视网膜色素上皮细胞培养液中发现的细胞因子 ,属于丝氨酸蛋白酶抑制剂基因家族 ,但不具备抗蛋白酶活性。 PEDF有营养神经效果 ,保护神经元免受快速神经毒性侵害 (如谷氨酸毒性 )作用及“胶质细胞静息”特性。PEDF还能抑制血管内皮细胞移行 ,促进血管内皮细胞凋亡 ,正常角膜、玻璃体中PEDF含量较高 ,在低氧环境中降低。PEDF具有抗新生血管诱导因子的作用 ,目前 PEDF被视为最有效的细胞内新生血管抑制因子之一。可能对治疗神经元损伤和抑制血管生成特别有效。 Pigment epithelium-derived factor (PEDF) is the first cytokine found in retinal pigment epithelial cell culture and belongs to serine protease inhibitor gene family, but does not have anti-protease activity. PEDF has a neurotrophic effect, protects neurons from the effects of rapid neurotoxicity such as glutamate toxicity, and “glial resting” properties. PEDF can also inhibit the migration of vascular endothelial cells, promote vascular endothelial cell apoptosis, normal cornea, vitreous PEDF content is higher, in hypoxia environment reduced. PEDF has an anti-angiogenic effect and PEDF is currently considered to be one of the most potent inhibitors of intracellular angiogenesis. It may be particularly effective at treating neuronal damage and inhibiting angiogenesis.