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目的探究血清同型半胱氨酸(HCY)、氧化低密度脂蛋白(OX-LDL)与急性脑梗死(ACI)的相关性。方法 90例急性脑梗死患者作为ACI组,按照梗死灶直径分为小梗死组、中梗死组、大梗死组,各30例;选择同期健康体检者30例作为对照组。运用酶循环法检测实验对象中血清HCY含量,运用酶联免疫吸附测定(ELISA)双抗体夹心法检测实验者OX-LDL的含量。结果 ACI各组中的HCY、OX-LDL比对照组明显增加,差异有统计学意义(P<0.05),且ACI各组间比较差异有统计学意义(P<0.05)。ACI患者的HCY与OX-LDL的含量呈正相关,且与患者的病情程度相关。结论 ACI的发生、发展与HCY与OX-LDL的含量存在明显的相关性。
Objective To investigate the correlation between serum homocysteine (HCY), oxidized low density lipoprotein (OX-LDL) and acute cerebral infarction (ACI). Methods 90 patients with acute cerebral infarction as ACI group, according to the diameter of infarction were divided into small infarction group, middle infarction group, large infarction group, 30 cases each; select the same period of 30 healthy subjects as a control group. Serum HCY levels were measured by enzyme-linked immunosorbent assay. OX-LDL levels were determined by enzyme-linked immunosorbent assay (ELISA) double antibody sandwich method. Results The levels of HCY and OX-LDL in the ACI groups were significantly higher than those in the control group (P <0.05), and there was significant difference between ACI groups (P <0.05). The ACY patients HCY and OX-LDL content was positively correlated, and with the severity of the patient’s condition. Conclusions There is a clear correlation between the occurrence and development of ACI and the content of HCY and OX-LDL.